Dispensing processes impact apparent biological activity as determined by computational and statistical analyses.

Dispensing and dilution processes may profoundly influence estimates of biological activity of compounds.Published data show Ephrin type-B receptor 4 IC50 values obtained via tip-based serial dilution and dispensing versus acoustic dispensing with direct dilution differ by orders of magnitude with no correlation or ranking of datasets.We generated

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A framework for facilitation of community participation in and beneficiation from CBT around the Save Valley Conservancy

Numerous developing countries recognize the latent possibilities of their natural resources for tourism growth and sustainability.Community based tourism initiatives are essentially cooperative actions by clusters of people in a community through which some small to medium scale homegrown tourism industry can be developed.There is thus a popular vi

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GlPRMT5 inhibits GlPP2C1 via symmetric dimethylation and regulates the biosynthesis of secondary metabolites in Ganoderma lucidum

Abstract PRMT5, a type II arginine methyltransferase, is involved in transcriptional regulation, RNA processing and other biological processes and signal transduction.Secondary metabolites are vital pharmacological compounds in Ganoderma lucidum, and their content is an important indicator for evaluating the quality of G.lucidum.Here, we found that

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Impact of Antibiotics on Efficacy of Cry Toxins Produced in Two Different Genetically Modified Bt Maize Varieties in Two Lepidopteran Herbivore Species, Ostrinia nubilalis and Spodoptera littoralis

The insecticidal crystal proteins from Bacillus thuringiensis (Bt) are widely-used biopesticides that are used both as Bt spore-crystal preparations in sprayable formulations and as activated toxins in genetically modified (GM) plants.Models for their modes of action have been proposed but many issues remain unresolved.Among those is the role of co

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